Withdrawal of generic budeprion for nonbioequivalence.

2463 transplantation — therapy that is associated with infertility and a greater risk of long­term toxic ef­ fects. These complications might have been avoided if such pa­ tients had been treated with mech­ lorethamine. Moreover, it is un­ known as yet whether salvage therapy has been successful in all patients who have had a relapse. Almost 80% of children and adolescents with cancer can be cured with current therapy. Most of the curative treatment regimens are based on chemotherapeutic agents that have been available for decades, but some of these have recently been in short sup­ ply. These shortages are likely to have devastating effects on pa­ tients with cancer and must be prevented. For many of these agents, no adequate substitute drugs are available. Our results suggest that even promising sub­ stitute regimens should be exam­ ined carefully before adoption; what might appear to be a suit­ able alternative regimen may re­ sult in an inferior outcome — an intolerable situation for young people with curable diseases.